Stanozolol – Wikipedia
Use as a Doping [edit | edit code]
One of the widely used steroid doping drugs. He was found in such runners as Ben Johnson, Olga Shishigina, Yulia Chermoshanskaya , bodybuilders Sean Ray and Nimrod King, in boxer James Toney, bobsledder Dmitry Trunenkov , as well as in many other athletes of various sports.
Despite the risk of developing virilism, stanozolol is used by women involved in strength sports as relatively less dangerous. Taking stanozolol leads to a greater extent not to a set of muscle mass, but to the relief of the main muscles .
If you take anabolic androgenic effects of testosterone for 1, then this coefficient for nandrolone will be 10 and for stanozolol – 30. Compared with testosterone, stanozolol is twice more active as an anabolic agent, and a third less active as androgen .
A study in 1986 showed that administering low doses of stanozolol cytomel and weight loss in bodybuilding (10 mg per day) to runners for 6 weeks did not give an increase in maximum speed and an anaerobic threshold, but significantly suppressed testosterone levels in the blood . According to another study, a two-week introduction of 10 mg of stanozolol to healthy men resulted in a 55% drop in blood testosterone levels and a number of other hormonal changes .
After the exact methods of detecting stanozolol were developed, its use in professional sports began to decline . Along with nandrolone, clenbuterol, methandrostenolone and methyltestosterone is included in the “big five” of doping drugs, which laboratories are obliged to determine with the maximum sensitivity .
Dosage Forms [edit | edit code]
Stanozolol is available in both oral and injectable forms. Injection stanozolol – aqueous suspension. With intramuscular administration, the effectiveness of stanozolol is approximately one and a half times higher.
Pharmacological action (according to the manufacturer)  [edit | edit code]
Penetrating into the cell nucleus, stanozolol activates the genetic apparatus of the cell, which leads to an increase in the synthesis of DNA, RNA and structural proteins, activation of enzymes of the link and enhancement of tissue respiration, oxidative phosphorylation, ATP synthesis and accumulation of macroergs in the cell. Stimulates anabolic and suppresses catabolic processes caused by glucocorticoids. It improves tissue trophism, promotes the deposition of calcium in the bones, retains nitrogen, phosphorus and sulfur in the body. Hematopoietic action is associated with an increase in the synthesis of erythropoietin. The antiallergic effect is due to an increase in the C1 concentration of the complement fraction. Androgenic activity may contribute to the development of secondary sexual characteristics of the male type.
Indications for medicinal use [edit | edit code]
In complex therapy:
Violation of protein synthesis, cachexia of different origin ;
Injuries, burns, pre- and postoperative periods, recovery period after infectious diseases and radiation ;
Toxic goiter, muscular dystrophy, osteoporosis, negative nitrogenous balance during corticosteroid therapy, hypo-and aplastic anemia .
Contraindications for medicinal use [edit | edit code]
Hypersensitivity to the drug components ;
Prostate cancer in men, breast cancer in women, breast carcinoma in women with hypercalcemia ;
Coronary heart disease, atherosclerosis ;
Hepatic and renal failure ;
Acute and chronic prostatitis ;
Period of pregnancy and lactation ;
Children’s age .
Side Effects [edit | edit code]
Similar to other steroids. Hepatotoxic (in oral and injectable forms), has a negative effect on the prostate.
May contribute to hair loss and the appearance of acne. The drug slightly inhibits the production of endogenous testosterone and does not cause gynecomastia.
In women, can lead to severe virilization. Stanozolol can also lead to high blood pressure , it increases the amount of “bad” cholesterol  (which can lead to coronary heart disease ). According to the manufacturer of stanozolol (strombafort), its use can cause in women depression of ovarian function, menstrual disorders, hypercalcemia . In men: the prepubertal period – symptoms of virilization, idiopathic hyperpigmentation of the skin, slowing or cessation of growth (calcification of the growth zones of the tubular bones), in the post-pubertal period – bladder irritation, gynecomastia, priapism ; in old age – hypertrophy and / or prostate carcinoma . Other side effects of the manufacturer include progression of atherosclerosis, peripheral edema, dyspeptic disorders, abnormal liver function with jaundice, changes in leukocyte formula, pain in long tubular bones, hypocoagulation with a tendency to bleed .
A 1989 study found that oral administration of 6 mg of stanozolol per day by weight lifters for 6 weeks resulted in a 33% decrease in high-density lipoprotein (“good cholesterol”) blood levels and a simultaneous increase in low-density lipoprotein (“bad cholesterol”) by 29 %; however, weight gain among those who took stanozolol approximately coincided with those participants in the study who took 200 mg of testosterone enanthate per week .
Notes [edit | edit code]